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KMID : 1098420230310020081
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Korean Journal of Medicinal Crop Science
2023 Volume.31 No. 2 p.81 ~ p.91
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Immune-boosting Effects of Chrysanthemum zawadskii Herbich var. latilobum Kitamura Extract on Cyclophosphamide-induced Immunosuppressed Sprague-Dawley Animal Model
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Park Young-Mi
Lee Hak-Yong
Shin Dong-Yeop
Lee Lawrence
Kim Jae-Gon
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Abstract
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Background : Chrysanthemum zawadskii Herbich var. latilobum Kitamura extracts (CZE) is used to treat of various inflammatory and chronic diseases. Although commonly adminstered, no reports suggest its potential usage as an immune-booster.
Methods and Results : In the cyclophosphamide (CP, 5 ㎎/㎏)-induced immunosuppression model, the immune-boosting effect of CZE (oral administration for 2 weeks with CP) was evaluated by investigating cell proliferation, activity of natural killer (NK) cells, cytotoxic T lymphocytes, and production of CP-repressed cytokines [such as tumor necrosis factor-α, interferon-γ, interluekin (IL)-2, and IL-12] in isolated splenocytes. In Vitro, CZE treatment enhanced cell proliferation, activity of NK cells and cytotoxic T lymphocytes activity, and production of CP-repressed cytokines. In Vivo, CZE treatment promoted the production of white blood cells, lymphocytes, medium-sized cells, and granulocytes and proliferation of NK cells in CP-induced immunosuppressed mice. Additionally, the CZE treatment restored the TNF-α and IL-12 reduced by CP to normal levels and prevented spleen tissue damage.
Conclusions : CZE could be an effective immune-booster and potentially be added to functional foods to enhance immunity.
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KEYWORD
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Chrysanthemum zawadskii Herbich var. latilobum Kitamura, Cyclophosphamide, Cytokine, Immune-boosting
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